Queen Victoria used St George's Chapel to an extent as a family chapel and in March 1863, during the early days of her widowhood, she chose the chapel as the place for the marriage of her son, Albert Edward, Prince of Wales, to Princess Alexandra of Denmark. The Queen was able to watch this ceremony from the privacy of the Catherine of Aragon closet, walking across to it from the Deanery, along an open pathway, where to this day, the rail is low, though the correct height for the Queen.

In 1863 Queen Victoria also converted the tomb house, partly built by Henry VII on the site of the original chapel, into a memorial chapel to Prince Albert. Here there are the memorial to the Prince Consort, and the tombs of Prince Albert Victor, Duke of Clarence and Prince Leopold, Duke of Albany.

As the Queen's reign continued, so she frequently visited the coffins of departed members of the family in the Albert Memorial Chapel and the Royal Vault.

She also placed many memorials in the chapel, including a statue to her 'Uncle Leopold', King of the Belgians, and husband of the ill-fated Princess Charlotte, and also a fine cenotaph in memory of the Prince Imperial, who died at the hands of the Zulus in 1879. This was originally in the Bray Chantry, but was moved in 1985 to a bay in the South Nave Aisle, its originally intended position, near the West Door. The Queen also placed a memorial to Prince Christian Victor, her grandson, who died in Pretoria from fever during the South African War, in 1900.

Queen Victoria's funeral in 1901 took place in the chapel, very delayed, due to the horses pulling the coffin, breaking their traces at Windsor station.